To work closely with laboratory staff to ensure that experimental aspects of in vitro DMPK transporter studies are performed to a high standard and within scheduled time frames.
There is currently a vacancy in the Drug Transporter group based in the Biohub at Alderley Park.
- Minimum of BSc in life science-related area preferably with experience (ca 1 year) of working within a laboratory environment. Direct experience in DMPK or transporter assays would be advantageous.
- Previous experience of laboratory processes and cell culture techniques is desirable.
- Knowledge and practical experience of drug transporter substrate or inhibition assays, working with radiolabelled substances and/or LC-MS/MS would be advantageous.
Principal Accountabilities (Lab Assistant)
- Support high and low throughput DMPK transporter assays for commercial as well as research and development activities.
- Perform work to a high quality, within specified timelines, and within safety regulations.
- Perform cell culture using aseptic techniques.
- Assist in data analysis and interpretation.
- Prepare compounds, stock solutions and buffers.
- Routine calibration of laboratory equipment.
- To follow safety regulations and quality control procedures.
Skills & Competencies
- Highly self-motivated and personable.
- Able to communicate effectively within a team environment.
- Able to organise daily tasks, to frequently work under pressure and to meet tight deadlines.
- Highly adaptable to work effectively in a dynamic environment.
- Possess excellent attention to detail, performing work to an exceptionally high standard, and within company and statutory safety regulations.
- Able to use initiative to solve problems and troubleshoot with the assistance of other members of the team.
- Should be computer literate with previous experience using Microsoft Office.
- To gain a knowledge and understanding of drug transporter assays and DMPK/ADMET processes in drug discovery and development.
- To work in a highly motivated commercial environment.
- To gain a sound understanding of the theory behind a variety of DMPK and ADMET assays including assay set up and validation.