Senior Scientist
Senior Scientist

Position Purpose:

To work closely with laboratory staff to ensure that experimental and data processing aspects of in vitro DMPK transporter studies are performed to a high standard and within scheduled time frames.

There is currently a vacancy in the Drug Transporter group based in the Biohub at Alderley Park.



  • Preferably a minimum of an MSc in a life science field with experience (minimum of 3 years) of working within a laboratory environment. Direct experience in DMPK transporter assays would be required.  Additionally, extensive experience of processing, critiquing and reporting data would be expected.
  • Strong knowledge of general laboratory processes is essential and experience in cell culture techniques is desirable.
  • Previous experience of in vitro cell-based or vesicle-based transporter assays via radiometric or LC-MS/MS endpoints is desirable.


Principal Accountabilities

  • Support high and low throughput DMPK transporter assays for commercial as well as research and development activities.
  • Responsible for planning, scheduling and conducting routine assays, and processing data to a high quality, within specified time frames.
  • To drive progress of assay development projects.
  • To work closely with the Information Systems team to improve internal systems and processes.
  • Help support and train Lab Assistants within the team.
  • To monitor and maintain stock consumables where required.
    • To be responsible for the validation and routine maintenance of laboratory equipment.
    • Perform cell culture using aseptic techniques.
    • Assist in data analysis and interpretation.
    • To follow safety regulations and quality control procedures.
  • To keep up to date with scientific advances, developments and regulatory guidelines in the area of drug transporter science and to inform the team of relevant developments.
  • Proactively takes responsibility to improve performance and efficiency of team processes.
  • To provide troubleshooting support.
  • Takes responsibility to improve performance without the need for guidance and effectively communicates this to the Team Leader /team.


Skills & Competencies

  • Highly self-motivated and personable.
  • Able to communicate effectively within a team environment.
  • Able to organise daily tasks, to frequently work under pressure and to meet tight deadlines.
  • Highly adaptable to work effectively in a dynamic environment.
  • Possess excellent attention to detail, performing work to an exceptionally high standard, and within company and statutory safety regulations.
  • Able to use initiative to solve problems and troubleshoot with the assistance of other members of the team.
  • Should be computer literate with previous experience using Microsoft Office.


Development Opportunities

  • To gain a knowledge and understanding drug transporter assays and how they are utilised for DMPK/ADMET processes in drug discovery and development.
  • To work in a highly motivated commercial environment.
  • To gain a sound understanding of the theory behind cell-based transporter assays including assay set up and validation.



More Information

For more information or to apply for this position, please contact Robert Elsby (  Closing date for applications is Friday 30th October 2015.